Publications

Bhattacharyya S., Bershtein S., Yan J., Argun T., Gilson AI., Trauger S., Shakhnovich EI. (2017) Transient protein-protein interactions perturb E.coli metabolome and cause gene dosage toxicity. eLife. 5. pii: e20309

Bershtein S., Serohijos AWR., Shakhnovich EI. (2016). Bridging the physical scales in evolutionary biology: From protein sequence space to fitness of organisms and populations. Curr Opin Struct Biol. 42:31-40

Rodrigues JV., Bershtein, S., Li, A., Lozovsky, E., Hartl, DL., Shakhnovich. EI. (2016). Biophysical Principles Predict Fitness Landscapes of Drug Resistance. PNAS. 113(13): E1964

Bershtein S, Serohijos AWR, Bhattacharyya S,  Manhart M, Choi J-M, Mu W,  Zhou J, Shakhnovich EI. (2015) Protein homeostasis imposes a barrier on functional integration of horizontally transferred genes in bacteria. PloS Genet. 11(10):e1005612

Palmer AC., Toprak E, Baym M, Kim S, Veres A, Bershtein S, Kishony R. (2015) Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes. Nat Commun. 6: 7385-7392.

Bershtein S, Choi J-M, Bhattacharyya S, Budnik B, Shakhnovich IE. (2015) Systems-level response to point mutations in a core metabolic enzyme modulates genotype-phenotype relationship. Cell Rep. 11: 645-56.

Bershtein S, Mu W, Serohijos AWR, Zhou J, Shakhnovich IE. (2013) Protein quality control acts on folding intermediates to shape the effects of mutations on organismal fitness. Mol Cell. 49: 133-44.

Bershtein S, Mu W, Shakhnovich IE. (2012) Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations. Proc Natl Acad Sci USA. 109: 4857-4862.

Bershtein S, Tawfik DS. (2008) Advances in laboratory evolution of enzymes. Curr Opin Chem Biol. 12: 151-158.

Bershtein S,  Tawfik DS. (2008) Ohno’s model revisited: Measuring the frequency of potentially adaptive mutations under various mutational drifts. Mol Biol Evol. 25: 2311-2318.

Bershtein S, Goldin K, Tawfik D.S. (2008) Intense neutral drifts yield robust and evolvable consensus proteins. J Mol Biol. 379: 1029-1044.

Bershtein S, Segal M, Bekerman R, Tokuriki N, Tawfik DS. (2006) Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein. Nature. 444: 929-932.