We use comparative genomics, microbial genetics, in vitro biochemical and biophysical characterization of protein structure and function, microfluidics-based single-gene evolution in artificial cells, and high-throughput microbial evolution empowered by robotics and deep sequencing analysis. (Check out the technology in the lab).
SINGLE-GENE EVOLUTION IN ARTIFICIAL CELLS
Water-in-oil emulsion droplets contain individual genes and cell-free transcription/translation system.
EVOLUTION OF MICROBIAL POPULATIONS
High-throughput experimental evolution of microbial populations.
Evolutionary adaptations of organisms and populations are tightly linked to the underlying biophysical properties of proteins